Tlhaloso e Khutšoanyane:
Nomoro ea CAS:51322-75-9
Foromo ea molek'hule:C9H8ClN5S
boima ba molek'hule:253.71
Sebopeho sa lik'hemik'hale:
| Litaba tsa Motheo | |
| Lebitso la sehlahisoa | Tizanidine |
| Kereiti | Sehlopha sa Pharma |
| Ponahalo | Phofo e Tshweu |
| Tlhahlobo | 99% |
| Shelf bophelo | lilemo tse 2 |
| Ho paka | 25kg / moropa |
| Boemo | Boloka ho -20°C |
Kemiso
Tizanidine ke motsoako oa imidazoline tse peli tsa nitrogen heterocyclic pentene. Sebopeho se tšoana le sa clonidine. Ka 1987, e ile ea qala ho thathamisoa Finland e le setsi sa adrenalin α2 receptor agonist. Hona joale, e sebelisoa e le setsi sa ho phomola mesifa e bohareng tleliniking. E ka sebelisoa ho tšoara mesifa e bohloko, e kang neck waist syndrome le torticollis. E ka boela ea sebelisoa ho phekola bohloko ba morao-rao, joalo ka disc herniation le ramatiki ea hip. E tsoa ho ankylosis ea mafu a methapo ea kutlo, joalo ka multiple sclerosis, chronic myelopathy, cerebrovascular accident, joalo-joalo.
Mosebetsi
E sebelisoa ho fokotsa tsitsipano ea mesifa ea masapo, mesifa ea mesifa le myotonia e bakoang ke kotsi ea boko le mokokotlo oa mokokotlo, ho tsoa mali a boko, encephalitis le multiple sclerosis.
Pharmacology
E fokotsa ka mokhoa o ikhethileng ho lokolloa ha li-amino acid tse hlasimollang ho tsoa ho li-interneuron le ho thibela mokhoa o mongata oa synaptic o amanang le khatello ea mesifa. Sehlahisoa sena ha se ame phetiso ea neuromuscular. E mamelloa hantle. E sebetsa hantle bakeng sa mesifa e bohloko e matla le ankylosis e sa foleng e tsoa mokokotlong le bokong. E ka fokotsa khanyetso ea motsamao o sa sebetseng, ea fokotsa spasticity le clonus, mme ea eketsa matla a motsamao oa boithaopo.
Lisebelisoa
E ngotsoe ke Tizanidine, e reretsoeng ho sebelisoa e le tekanyetso ea ka hare bakeng sa tekanyo ea Tizanidine ka GC- kapa LC-mass spectrometry. Tizanidine e ka ba le ts'ebeliso ea kalafo joalo ka SARS-CoV-2 main protease inhibitor.
Tšebeliso ea Clinical
Tizanidine ke setsi sa adrenergic α2 receptor agonist e sebelisoang ho phekola maemo a sa foleng a mesifa, joalo ka multiple sclerosis.
Mokhoa oa ts'ebetso
Tizanidine ke analogue e khathollang ea mesifa e bohareng ea clonidine e amoheloang hore e sebelisoe ho fokotsa spasticity e amanang le kotsi ea boko kapa mokokotlo oa mokokotlo. Mokhoa oa eona oa ts'ebetso oa ho fokotsa spasticity o fana ka maikutlo a ho thibela presynaptic ea li-motor neurons hoαLiwebsaete tsa 2-adrenergic receptor, ho fokotsa ho lokolloa ha li-amino acid tse tsosang takatso le ho thibela litsela tsa ceruleospinal tse thusang, kahoo li fella ka ho fokotseha ha spasticity. Tizanidine e na le karoloana e nyane feela ea ketso ea antihypertensive ea clonidine, mohlomong ka lebaka la ts'ebetso ea sehlotšoana se ikhethileng.α2C-adrenoceptors, tse bonahalang li ikarabella bakeng sa ts'ebetso ea analgesic le antispasmodic imidazolineα2-agonists(20).
