Tlhaloso e Khutšoanyane:
Nomoro ea CAS: 69004-03-1
Foromo ea molek'hule:C18H14F3N3O4S
boima ba molek'hule: 425.38
Sebopeho sa lik'hemik'hale:
| Litaba tsa Motheo | |
| Lebitso la sehlahisoa | Toltrazuril |
| Nomoro ea CAS. | 69004-03-1 |
| Mmala | Phofo ea kristale e tšoeu kapa e batlang e le tšoeu |
| Kereiti | Fepa Kereiti |
| Polokelo | E tiisitsoe ka ho omme, Mocheso oa Kamore |
| Shelf Life | lilemo tse 2 |
| Sebelisa | Likhomo, Khoho, Ntja, Litlhapi, Pere, Kolobe |
| Sephutheloana | 25kg/moropa |
Tlhaloso
Toltrazuril (Baycox®,Procox®) ke moriana oa triazinon o nkang anticoccidial le antiprotozoalactivity ka bongata. Ha e fumanehe khoebong United States, empa e fumaneha linaheng tse ling. E sebetsa khahlano le mekhahlelo ea thobalano le ea thobalano ea coccidia ka ho thibela karohano ea nyutlelie ea li-schizonts le li-microga-monts le 'mele e etsang lebota ea macrogamont. E ka boela ea thusa ho phekola porcinecoccidiosis ea lesea, EPM, le canine hepatozoonosis.
Toltrazuril le metabolite ponazuril ea eona e kholo (toltrazuril sulfone, Marquis) ke litlhare tsa antiprotozoal tse thehiloeng ho triazine tse nang le ts'ebetso e ikhethileng khahlanong le mafu a apicomplexan coccidial. Toltrazuril ha e fumanehe ka hare ho United States.
Tšebeliso ea sehlahisoa
Swine: Toltrazuril e bontšitsoe ho fokotsa matšoao a coccidiosis likolobe tse anyesang tse tšoaelitsoeng ka tlhaho ha molomo o le mong oa 20–30 mg/kg BWdose o fuoa 3 ho likolobe tsa matsatsi a 6 (Driesen et al., 1995). Matšoao a kliniki a fokotsehile ho tloha ho 71 ho ea ho 22% ea likolobe tse anyesang, 'me letšollo le ho tsoa ha oocyst le tsona li fokotsehile ka phekolo e le' ngoe ea molomo. Lihlahisoa tse amohetsoeng li na le nako ea matsatsi a 77 ea ho tsoa United Kingdom.
Manamane le likonyana: Toltrazuril e sebelisoa ho thibela matšoao a coccidiosis le phokotso ea ho tšolla ha coccidia manamaneng le likonyana joalo ka kalafo ea lethal dose le le leng. Linako tsa ho ntša chelete United Kingdom ke matsatsi a 63 le a 42 bakeng sa manamane le likonyana, ka ho latellana.
Lintja: Bakeng sa hepatozoonosis, toltrazuril e fanoang ka molomo ka 5 mg/kg BW lihora tse ling le tse ling tse 12 ka matsatsi a 5 kapa e fanoa ka molomo ka 10 mg/kg BW lihora tse ling le tse ling tse 12 bakeng sa matsatsi a 10 e baka phokotso ea matšoao a kliniki ho lintja tse tšoaelitsoeng ka tlhaho matsatsing a 2-3. Macintire et al., 2001). Ka bomalimabe, boholo ba lintja tse neng li phekoloa li ile tsa khutlela mokhoeng oo ’me qetellong tsa shoa ka lebaka la hepatozoonosis. Ka malinyane a nang le Isospora sp. tšoaetso, kalafo ka 0.45 mg emodepside hammoho le 9 mg/kg BW toltrazuril (Procox®, Bayer Animal Health) e fokotsa palo ea oocyst ea mantle ka 91.5–100%. Ho ne ho se na phapang pakeng tsa nako ea letšollo ha phekolo e ne e qala ka mor'a ho qala ha matšoao a kliniki nakong ea tšoaetso ea patent (Altreuther et al., 2011).
Likatse: Likatseng tse tšoaelitsoeng ka liteko tsa Isospora spp., kalafo ka lethal dose le le leng la molomo la 0.9 mg emodepside hammoho le 18 mg/kg BW toltrazuril (Procox®, Bayer AnimalHealth) e fokotsa ho tsoa ha oocyst ka 96.7–100% ha e fanoa nakong ea pelehi nako (Petry et al., 2011).
Lipere: Toltrazuril e boetse e sebelisetsoa ho phekola EPM. Sethethefatsi sena se bolokehile, leha se le maemong a holimo. Liphekolo tse khothaletsoang hona joale ke 5-10 mg/kg ka molomo bakeng sa matsatsi a 28. Leha e na le ts'ebetso e ntle ea toltrazuril, ts'ebeliso ea eona e fokotsehile ho lipere ka lebaka la ho fumaneha ha litlhare tse ling tse sebetsang hantle.
