Tlhaloso e Khutšoanyane:
Nomoro ea CAS: 59-05-2
Foromo ea molek'hule: C20H22N8O5
boima ba molek'hule: 454.45
Sebopeho sa lik'hemik'hale:
| Litaba tsa Motheo | |
| Lebitso la sehlahisoa | Methotrexate |
| Kereiti | sehlopha sa meriana |
| Ponahalo | phofo ea crystalline e mosehla oa lamunu. |
| Tlhahlobo | 99% |
| Shelf bophelo | lilemo tse 2 |
| Ho paka | 25kg / lebokose |
| Sebopeho | E tsitsitse, empa e bobebe ebile e hygroscopic. Ha e lumellane le li-acid tse matla, li-oxidizing agents tse matla. |
| Boemo | Boloka sebakeng se lefifi, se se nang moea, Boloka ka sehatsetsing, ka tlas'a -20°C |
Methotrexate ke eng?
Methotrexate e na le kutloelo-bohloko ho hydrolysis, oxidation le leseli. Ha e kenelle ka metsing. Methotrexate e bola maemong a asiti haholo kapa a alkaline. Methotrexate ha e tsamaisane le li-oxidizing tse matla le li-acid tse matla.
Methotrexate ke sethethefatsi se sebelisetsoang ho phekola mofetše, o tsejoang hape e le lithethefatsi tsa cytotoxic. E le ho fokotsa cytotoxicity, e ka sebelisoa hammoho le calcium leucovorin. E sebelisoa haholo-holo bakeng sa phekolo ea acute leukemia (acute lymphocytic leukemia), kankere ea matsoele, mole e kotsi le choriocarcinoma, mofetše oa hlooho le molala, kankere ea masapo, leukemia, mokokotlo oa mokokotlo oa meningeal, kankere ea matšoafo, kankere ea tsamaiso ea ho ikatisa, kankere ea sebete, refractory. psoriasis vulgaris, dermatomyositis, 'mele myositis, ankylosing spondylitis ho ruruha, lefu la Crohn, psoriasis le psoriatic ramatiki, lefu la Behcet le lefu la autoimmune. Methotrexate ke immuno suppressant mme e ka sebelisoa bakeng sa ho nolofatsa ts'ebetso ea rheumatism ka katleho e ntle haholo ea ho phekola ho ruruha ha synovial ea ramatiki ea ramatiki mme ke lithethefatsi tse sebelisoang khafetsa bakeng sa ho alafa mafu a ramatiki.
Kopo ea bongaka
E sebetsa hantle ho phekola acute leukemia ka katleho e ntle ho bakuli ba bana. E na le ts'ebetso e ntle ea ho phekola choriocarcinoma le mole e kotsi. Tsamaiso e kholo ea lethal dose e sebetsa hantle ho phekoleng osteosarcoma, sarcoma ea lisele tse bonolo, mofetše oa matšoafo, mofetše oa testicular, mofetše oa matsoele le mofetše oa mahe a bomme. E boetse e sebetsa ho phekola mofetše oa hlooho le molala, kankere ea sebete le kankere ea mala. Infusion ea arterial ea sehlahisoa sena e na le ts'ebetso e ntle ea ho phekola mofetše oa hlooho le molala le mofetše oa sebete. Leha ho le joalo, ha e sebelisoe hangata ho phekola psoriasis le psoriasis.
