Letlapa la Folate (Folic Acid, Vit B9)

Tlhaloso e Khutšoanyane:

Round, Oval, Oblong, Triangle, Diamond le libopeho tse ling tse ikhethang kaofela li teng.

disetifikeiti

Lintlha tsa Sehlahisoa

Li-tag tsa Sehlahisoa

Litaba tsa Motheo
Lebitso la sehlahisoa	Matlapa a Folate
Mabitso a mang	Letlapa la Folic Acid, Letlapa la Folate le Buletsoeng, Letlapa le sebetsang la Folic Acid, joalo-joalo.
Kereiti	Boemo ba lijo
Ponahalo	Joalo ka litlhoko tsa bareki Round, Oval, Oblong, Triangle, Diamond le libopeho tse ling tse ikhethang kaofela li teng.
Shelf bophelo	Lilemo tse 2-3, ho latela maemo a polokelo
Ho paka	Bongata, libotlolo, lipakete tsa blister kapa litlhoko tsa bareki
Boemo	Boloka ka lijaneng tse thata, tse sirelelitsoeng leseli.

Tlhaloso

Liphello tsa folic acid ho likokoana-hloko li bonahala haholo-holo likarolong tse latelang: ho kenya letsoho metabolism ea liphatsa tsa lefutso le protheine; ho ama ts'ebetso ea ho ikatisa ea liphoofolo; e amang secretion ea manyeme a liphoofolo; ho khothalletsa ho hōla ha liphoofolo; le ho ntlafatsa tšireletso ea 'mele.

Methyltetrahydrofolate hangata e bolela 5-methyltetrahydrofolate, e nang le mosebetsi oa ho matlafatsa 'mele le ho tlatsetsa folic acid. 5-Methyltetrahydrofolate ke ntho e nang le mesebetsi e sebetsang e fetoloang ho tloha ho folic acid ka letoto la liketso tsa lik'hemik'hale 'meleng oa motho. E ka sebelisoa ka kotloloho ke 'mele litseleng tse fapaneng tsa metabolic ho boloka ts'ebetso e tloaelehileng ea' mele, ka hona e bapala karolo ea ho fepa 'mele.

Mosebetsi

Folic acid ke mofuta oa livithamini tsa B, tse tsejoang hape e le pteroylglutamic acid. 5-methyltetrahydrofolate ke mohato oa ho qetela oa metabolism le phetoho ea folic acid 'meleng. Ka lebaka la ts'ebetso ea eona e sebetsang, e boetse e bitsoa mafolofolo. Folic acid ke karolo ea metabolism ea folic acid 'meleng.

Hobane sebopeho sa limolek'hule sa 5-methyltetrahydrofolate se ka kenngoa ka kotloloho ke 'mele ntle le ho etsa lits'ebetso tse rarahaneng tsa phetoho ea metabolic, e teng ka bongata liseleng tsa' mele. Ha ho bapisoa le folic acid, ho bonolo ho eketsa limatlafatsi bakeng sa 'mele, haholo-holo ho basali ba hlokang ho itokisetsa ho ima le bakhachane nakong ea bokhachane.

Folic acid ke e 'ngoe ea livithamine tsa bohlokoa bakeng sa kholo le ho ikatisa ha lisele tsa' mele. Khaello ea eona e tla ama mesebetsi e tloaelehileng ea 'mele oa motho. Lingoliloeng tse ngata li tlalehile hore khaello ea folic acid e amana ka ho toba le bokooa ba neural tube, megaloblastic anemia, petso ea molomo le mahalapa, khatello ea maikutlo, lihlahala le mafu a mang.

Ho senyeha ha methapo ea kutlo (NTDs)

Neural tube malformations (NTDs) ke sehlopha sa bokooa bo bakoang ke ho koaloa ho sa phethoeng ha methapo ea methapo nakong ea tsoelo-pele ea lesea, ho akarelletsa le anencephaly, encephalocele, spina bifida, joalo-joalo, 'me ke e' ngoe ea liphoso tse tloaelehileng ka ho fetisisa tsa lesea. Ka 1991, British Medical Research Council e ile ea tiisa ka lekhetlo la pele hore folic acid supplementation pele le ka mor'a bokhachane e ka thibela ho hlaha ha NTDs le ho fokotsa sekhahla ka 50-70%. Tšusumetso ea thibelo ea folic acid ho li-NTD e nkuoe e le e 'ngoe ea litšibollo tse monate tsa bongaka bofelong ba lekholo la bo20 la lilemo.

Megaloblastic anemia (MA)

Megaloblastic anemia (MA) ke mofuta oa phokolo ea mali e bakoang ke ho senyeha ha DNA synthesis e bakoang ke khaello ea folic acid kapa vithamine B12. E atile haholo ho masea le bakhachane. Khōlo e tloaelehileng ea lesea le ka pōpelong e hloka palo e kholo ea li-folic acid tse bolokiloeng 'meleng oa' mè. Haeba pokello ea folic acid e fokotsehile nakong ea pelehi kapa ka mor'a ho pepa, megaloblastic anemia e tla hlaha ka pōpelong le ho 'm'a. Ka mor'a ho tlatsetsa ka folic acid, lefu lena le ka fola kapele 'me la phekoloa.

Folic acid le molomo o phatlohileng le mahalapa

Cleft lip and palate (CLP) ke e 'ngoe ea likoli tse atileng haholo tsa tsoalo. Sesosa sa ho petsoha ha molomo le mahalapa ha se e-so hlake. Folic acid supplementation nakong ea bokhachane ba pele e pakiloe hore e thibela tsoalo ea bana ba nang le melomo le mahalapa.

Mafu a mang

Ho haella ha folic acid ho ka baka kotsi e kholo ho bo-mme le bana, joalo ka tloaelo ea ho senyeheloa ke mpa, tsoalo ea pele ho nako, boima ba 'mele bo tlase, ho se sebetse hantle ha lesea le ho hola ha lesea. Lingoliloeng tse ngata li tlaleha hore lefu la Alzheimer, khatello ea maikutlo, le ho se tloaelehe ha methapo ho masea a sa tsoa tsoaloa le maqeba a mang a amanang le boko kaofela li amana le khaello ea folic acid. Ho phaella moo, ho haella ha folic acid ho ka boela ha baka lihlahala (kankere ea popelo, kankere ea bronchial, kankere ea 'metso, kankere ea mala, joalo-joalo), atrophic gastritis, colitis, lefu la pelo le lefu la cerebrovascular, hammoho le mafu a mang a kang glossitis le kgolo e mpe. Batho ba baholo ba haelloang ke folic acid le ho noa joala ho feta tekano ba ka fetola sebopeho sa mala a bona a mala.