Tlhaloso e Khutšoanyane:
Nomoro ea CAS: 1264-72-8
Foromo ea molek'hule:2(C52H98N16O13).5(H2SO4)
boima ba molek'hule: 2801.27
Sebopeho sa lik'hemik'hale:
| Litaba tsa Motheo | |
| Lebitso la sehlahisoa | Colistin sulfate |
| Kereiti | Fepa Kereiti |
| Ponahalo | E tšoeu kapa e batla e le tšoeu, phofo ea hygroscopic |
| Tlhahlobo | 99% |
| Shelf bophelo | lilemo tse 2 |
| Ho paka | 20kg/carton 20kg/drum |
| Boemo | Boloka ho -20 ℃ selemo se le seng（Phofo） |
Tlhaloso ea sehlahisoa
Colistin ke cyclic cationic decapeptide e hokahantsoeng le ketane ea mahlakoreng a mafura a acid, ke ea sehlopha sa li-peptide tsa antimicrobial tse hlophisitsoeng ka tsela e tšoanang. Colistin sulfate ke lithibela-mafu tsa polypeptide tse thibelang libaktheria tsa gram-negative ka ho tlama lipopolysaccharides le phospholipids ka har'a lera le ka ntle la lisele tsa baktheria ea gram-negative.
Colistin sulfate, eo hape e tsejoang e le colistin sulfate, Christian (Colistin), Polymyxin E(Polymyxin E), antiphytin, phofo e tšoeu kapa e batlang e le tšoeu, e sa nkhang hamonate, mongobo o monate, o qhibiliha habonolo metsing, o qhibiliha hanyenyane ka methanol, ethanol, hoo e batlang e sa qhibilihe ka metsing. acetone, ether, alkali ea mahala e qhibiliha hanyane ka metsing. E tsitsitse ho PH3-7.5 mefuta e mengata. Mycolistin sulfate e hlahisoa ke Bacillus polymyxoides, e nang le phello e matla ea antibacterial ho libaktheria tsa gram-negative. E sebelisoa ho phekola mafu a mala a bakoang ke libaktheria tsa gram-negative, 'me e sebelisoa e le motsoako oa lijo tse nang le phello e hlakileng ea ho hōlisa. Motsoako oa phello ea sulfadiazine o betere.
Mosebetsi oa sehlahisoa
Li-granules tsa Colistin sulfate li ntlafalitse botsitso ba potency lijong le ho bonts'a ho qhibiliha ho hoholo ho sa tsotellehe ho hlahisoa ha tsona ntle le ho sebelisa mochine o theko e boima kapa thepa e khethehileng. Haholo-holo, colistin sulfate granules e nang le colistin sulfate 'me e na le bophara ba likaroloana tse 150 ho isa ho 1500m, sebaka se itseng sa 40 ho isa ho 500 cm2 / g, nako ea ho koloba ea metsotso e 5 kapa ka tlase le mongobo oa 10% kapa ka tlase.
Pharmacodynamics
Colistin ke moemeli oa lithibela-mafu oa polymyxin. Li-polymyxins ke cationic polypeptides tse senyang lera la sele ea baktheria ka mochine o kang oa sesepa. Ka nts'etsopele ea lintho tse nang le chefo e fokolang, joalo ka penicillins le cephalosporins, ts'ebeliso ea polymyxin ea parenteral e ile ea lahloa haholo, ntle le kalafo ea mafu a matšoafo a hanyetsanang le lithethefatsi ho bakuli ba nang le cystic fibrosis.
