Tlhaloso e Khutšoanyane:
Nomoro ea CAS:24729-96-2
Mokhoa oa limolek'hule: C18H34ClN2O8PS
boima ba molek'hule: 504.96
Sebopeho sa lik'hemik'hale:
| Litaba tsa Motheo | |
| Lebitso la sehlahisoa | Clindamycin Phosphate |
| Kereiti | Sehlopha sa Pharma |
| Ponahalo | phofo e tshweu |
| Tlhahlobo | 95% |
| Shelf bophelo | lilemo tse 2 |
| Ho paka | 25kg / moropa |
| Boemo | E tsitsitse, empa boloka e pholile. Ha e lumellane le li-oxidizing agents tse matla, calcium gluconate, barbiturates, magnesium sulfate, phenytoin, divithamini ea sodium ea sehlopha sa B. |
Tlhaloso
Clindamycin phosphate ke ester e qhibilihang ka metsing ea lithibela-mafu tsa semisynthetic tse hlahisoang ke 7 (S) -chloro-substitution ea 7 (R) -hydroxyl sehlopha sa lithibela-mafu tsa motsoali, lincomycin. E tsoa ho lincomycin (lincosamide). E na le ts'ebetso ea bacteriostatic khahlano le li-aerobes tsa Gram-positive le mefuta e mengata e fapaneng ea anaerobicbacteria. Ke lithibela-mafu tse sebelisoang ho phekola mafu. Tsena li ka kenyelletsa tšoaetso ea pampiri ea ho hema, septicaemia, peritonitis le mafu a masapo. E boetse e sebelisoa ho phekola li-acne tse itekanetseng ho isa ho tse matla.
Sebelisa
Clindamycin phosphate e sebelisoa ka holimo e le 'ngoe kapa hammoho le benzoyl peroxide kalafo ea inflammatory acne vulgaris. Ha ho lekoa melemo e ka bang teng ea kalafo ea topical clindamycin, ho lokela ho nahanoa monyetla oa litlamorao tse mpe tsa GI tse amanang le moriana. Phekolo ea li-acne vulgaris e tlameha ho etsoa ka bomong le ho fetoloa khafetsa ho latela mefuta ea makhopho a atileng le karabelo ea kalafo. Li-anti-infectives tse ka sehloohong, ho kenyelletsa le clindamycin, hangata li sebetsa hantle kalafong ea makhopho a bobebe ho isa ho a itekanetseng. Leha ho le joalo, tšebeliso ea li-anti-infectives tsa lihlooho tse kang monotherapy e ka lebisa ho hanyetsanang le baktheria; khanyetso ena e amahanngoa le ho fokotseha ha matla a kliniki.Clindamycin ea sehlooho e thusa haholo ha e sebelisoa le benzoyl peroxide kapa topical retinoids. Liphetho tsa lithuto tsa kliniki li bonts'a hore kalafo e kopaneng e fella ka phokotso ea lipalo tse felletseng tsa liso ka 50-70%.
Clindamycin 2-phosphate ke letsoai la clincamycin, semi-synthetic lincosamide. Letsoai le lokisoa ka ho khetha phosphorylation ea 2-hydroxy moiety ea tsoekere ea clindamycin. Ho kenngoa ha phosphate ho fana ka ho qhibiliha ho ntlafetseng bakeng sa metsoako ea ente. Joalo ka litho tse ling tsa lelapa la lincosamide, clindamycin 2-phosphate ke lithibela-mafu tse pharalletseng tse nang le ts'ebetso khahlano le libaktheria tsa anaerobic le protozoans. Clindamycin e sebetsa ka ho tlama ho 23S ribosomal subunit, e thibela protheine synthesis.
