Tlhaloso e Khutšoanyane:
Nomoro ea CAS: 472-15-1
Mokhoa oa limolek'hule: C30H48O3
boima ba molek'hule: 456.71
Sebopeho sa lik'hemik'hale:
| Litaba tsa Motheo | |
| Lebitso la sehlahisoa | Asiti ea betulinic |
| Kereiti | Sehlopha sa Pharma |
| Ponahalo | Bosoeu kapa bosoeu bo bosootho |
| Tlhahlobo | 98% |
| Shelf bophelo | lilemo tse 2 |
| Ho paka | 25kg / moropa |
| Boemo | E tsitsitse, empa boloka e pholile. Ha e lumellane le li-oxidizing agents tse matla, calcium gluconate, barbiturates, magnesium sulfate, phenytoin, divithamini ea sodium ea sehlopha sa B. |
Tlhaloso
Betulinic acid (472-15-1) ke Lupane triterpenoid ea tlhaho ho tloha sefateng se sesoeu sa birch (Betula pubescens). E etsa hore ho be le apoptosis ka mefuta e sa tšoaneng ea lisele.1 E etsa hore mitochondrial permeability transition pore e bulehe.
Sebelisa
Betulinic Acid ke pentacyclic triterpenoid ea tlhaho. Betulinic Acid e bontša tšebetso e khahlanong le ho ruruha le e khahlanong le HIV. Betulinic Acid ka mokhoa o ikhethileng e kenya apoptosis liseleng tsa hlahala ka ho kenya tšebetsong tsela ea mitochondrial ea apoptosis ka mokhoa o ikemetseng oa p53- le CD95. Betulinic Acid e boetse e bonts'a ts'ebetso ea agonist ea TGR5.
Betulinic acid (BetA) e sebelisitsoe:
1.ho lekola litlamorao tsa eona joalo ka moemeli oa antiviral khahlano le kokoana-hloko ea Dengue (DENV).
2.e le sterol regulatory element-binding protein (SREBP) inhibitor ho hatella metabolism ea lipid le ho ata ha lisele tse hlakileng tsa renal cell carcinoma (ccRCC).
3.e le kalafo ea ho lekola thepa ea eona ea anti-tumor bakeng sa ho sebetsa ha sele le liteko tsa lefu la lisele tsa apoptotic ka mefuta e mengata ea myeloma.
Patlisiso ea Anticancer
Motsoako ona ke pentacyclic triterpene e fumanoang mefuteng ea Betula le Zizyphus, e bonts'ang cytotoxicity e ikhethileng khahlanong le lisele tsa melanoma ea motho (Shoeb2006). E hlahisa mefuta e mengata ea oksijene e sebetsang, e kenya tšebetsong MAPK cascade, inhibitstopoisomerase I, inhibits angiogenesis, modulates pro-growth transcriptionalactivators, e fetola mosebetsi oa aminopeptidase-N, 'me ka tsela eo e kenya poptosis liseleng tsa mofetše (Desai et al. 2008; Fulda 2008).
Mosebetsi oa Likokoana-hloko
Triterpenoid ea tlhaho e bonts'ang ts'ebetso e khahlanong le HIV le antitumor. E etsa hore ho be le mefuta e mengata ea oksijene e sebetsang (ROS) le ho kenya tšebetsong NF- κ B. Lipontšo tsa TRG5 agonist (EC 50 = 1.04 μ M).
Liketso tsa Biochem/physiol
Betulinic acid, pentacyclic triterpene, ka mokhoa o ikhethileng e kenya apoptosis liseleng tsa hlahala ka ho kenya tšebetsong tsela ea mitochondrial ea apoptosis ka mokhoa o ikemetseng oa p53- le CD95.
